Weight loss injections: Understanding the Risks and Benefits of Mounjaro and Wegovy injections for Weight Management
- Mamta Nitesh Joshi
- Feb 27
- 4 min read
Updated: Mar 4
In a world where health and wellness are more important than ever, many people are turning to new solutions for weight management. Among these solutions are GLP1 (glucagon-like peptide-1) and dual agonist injections. These medications promise to aid in weight loss and improve overall health. But do you really need them? This guide will help you understand your appetite, the challenges of metabolism, and the impact of excess weight on conditions like diabetes, fertility, osteoarthritis, and sleep apnea.
By exploring how these injections work, evaluating their potential risks, and providing clear options, this article aims to equip you with the knowledge to make informed choices about your health and well-being.
Understanding Your Appetite and Metabolism: ITS NOT ME!
We have come to recognise that obesity is a complex disease, contributed by combination of genetic and environmental factors. The inflammation with the fat or adipose tissue further worsens when there is energy excess, more than the body can handle. This inflammation, though initiated by genetic factors or environmental influence of gut microbes, processed foods, endocrine disruptors, could then start the spiral downward of disease progression.
The excess fat tissue builds up in unhealthy locations of body, where you typically do not expect it to stay, such as around the internal organs, can disrupt these signals, leading to increased health risks, particularly diabetes. For instance, nearly 34 million Americans, about 10.5% of the population, have diabetes, which significantly affects the body’s ability to manage blood sugar. This condition often comes with an elevated appetite and a slower metabolism, making it hard to manage weight effectively.
Moreover, excess weight can lead to fertility issues. Studies show that overweight women are 5 times more likely to experience difficulties with ovulation. Additionally, people with higher body weights are at increased risk of osteoarthritis; research indicates that for every 5 kg increase in weight, the risk of developing this joint condition rises by 36%. Sleep apnea is another concern. Individuals struggling with obesity are 2 to 3 times more likely to develop this disorder, which negatively impacts sleep quality and overall health.
Understanding these connections can help you make better decisions about your health.
The Mechanisms Behind GLP1 and Dual Agonist Injections
GLP1 agonists like Semaglutide mimic the action of the GLP1 hormone, which aids in glucose metabolism and appetite control. They work by enhancing insulin secretion, slowing gastric emptying, and increasing feelings of fullness. These actions can lead to noticeable weight loss, giving hope to many facing challenges related to weight and metabolic health.
Dual agonists such as Tirzepatide take it a step further by combining GLP1 agonism with additional hormonal pathways. This combination targets multiple metabolic factors, potentially leading to greater success in weight loss and improvements in overall health for patients.

Weighing the Risks
While GLP1 and dual agonist injections present benefits, it is crucial to assess the risks involved. Recent studies have highlighted several potential side effects, some of which are worth being aware of:
sudden tummy pain and vomiting could be sign of pancreatitis, gall stones or severe intestinal issues
vomiting could lead to dehydration, which may be unsafe for individuals with existing kidney disease
allergic reactions, hair loss, palpitations, worsening of diabetes related eye disease, can also occur.
The side effects appear to be higher for those with lower body weights.
It’s essential to consult with a healthcare professional to consider your personal health profile, including pre-existing conditions, before starting these medications.
Given that recent statistics indicate a small percentage of individuals may face serious complications, it’s wise to approach these treatments with caution. They can offer benefits but are not a universal answer for everyone.

Making Informed Choices
Choosing how to manage your weight should involve more than just considering injections. Embracing a holistic approach can empower you to achieve sustainable results. I have specifically written about weight loss strategies in another blog.
Eat Differently
Nutrition plays a crucial role in weight management. Focus on integrating whole foods that are rich in nutrients, fibre, and protein into your diet. Aim for a plate filled with colourful vegetables, fruits, lean proteins, and whole grains. For example, replacing processed snacks with fresh fruits can improve your nutrient intake while naturally regulating hunger.
Exercise More
Incorporating regular physical activity into your daily routine is essential to prevent injections related muscle loss. Engaging in activities like brisk walking, running, or cycling can elevate your metabolic rate, boost your mood, and enhance weight loss efforts. Strength training is also vital, as it builds muscle and increases the number of calories burned at rest.

Consultation with Professionals
Before starting any medication or making significant lifestyle changes, consulting with a healthcare professional is invaluable. It is sad to see that some people who have put in their heart and soul into making lifestyle changes, are eventually diagnosed hormonal diseases which have alternative treatment options.
Navigating Your Health Decisions
Deciding whether GLP1 or dual agonist injections are necessary for you involves careful consideration of your health status. It is essential to grasp the complexities of your appetite, metabolism, and how excess weight influences your well-being.
By weighing the benefits against the risks, adopting a balanced diet, committing to regular exercise, and seeking professional guidance, you can make more informed decisions about your health. The ultimate goal is to discover a sustainable way to manage your weight and enhance your overall well-being, tailored specifically to your needs.
Empower yourself with information and approach your weight management journey with confidence.
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